Abstract
Two new lignan glycosides, named larrealignans A (1) and B (2), and a known lignan (3) were isolated from the aerial parts of Larrea tridentata (Zygophyllaceae). The structures of 1 and 2 were determined on the basis of spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds (1-3) and aglycones (1a, 2a) of 1 and 2 were evaluated for their cytotoxic activities against HL-60 human leukemia cells.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Drug Screening Assays, Antitumor
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HL-60 Cells
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Humans
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Larrea / chemistry*
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Leukemia / drug therapy
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Lignans / chemistry*
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Lignans / isolation & purification
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Lignans / pharmacology*
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Plant Components, Aerial / chemistry
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Spectrum Analysis
Substances
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Antineoplastic Agents, Phytogenic
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Lignans