Noise reduction by signal combination in Fourier space applied to drift correction in optical tweezers

Rev Sci Instrum. 2011 Nov;82(11):115103. doi: 10.1063/1.3658825.

Abstract

A general method is proposed to reduce noise by combining signals. Different measurements of the same physical quantity often exhibit different noise levels in different frequency ranges. Hence, a single high-fidelity signal can be constructed by combining the low-noise parts of the signals in Fourier space. We demonstrate this method by reducing noise in the measured bead-to-bead distance in an optical tweezers setup.