Abstract
Human T-cell lymphoma virus (HTLV)-1 was the first human retrovirus to be discovered. It has been recognized as the cause of adult T-cell leukemia (ATL). In addition to giving a historical perspective on HTLV-1 and other retrovirus research, this paper discusses the origin of HTLV-1; the modes of transmission and global epidemiology of HTLV-1 infection; the genome of HTLV-1 and the mechanism of HTLV-1-induced leukemogenesis; the role of HTLV-1 in other diseases, and recent breakthroughs in ATL therapy.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
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Adult
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Animals
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Antiviral Agents / administration & dosage
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Antiviral Agents / therapeutic use*
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Arsenic / administration & dosage
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Arsenic / therapeutic use
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Cell Proliferation
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Cell Transformation, Viral / genetics*
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HTLV-I Infections / complications
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HTLV-I Infections / drug therapy
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HTLV-I Infections / epidemiology*
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HTLV-I Infections / transmission
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HTLV-I Infections / virology
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Host-Pathogen Interactions
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Human T-lymphotropic virus 1 / genetics*
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Human T-lymphotropic virus 1 / pathogenicity
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Humans
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Interferons / administration & dosage
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Interferons / therapeutic use
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Leukemia-Lymphoma, Adult T-Cell / drug therapy
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Leukemia-Lymphoma, Adult T-Cell / epidemiology*
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Leukemia-Lymphoma, Adult T-Cell / etiology
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Leukemia-Lymphoma, Adult T-Cell / virology
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Mice
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Mice, Transgenic
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Viral Proteins / chemistry
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Viral Proteins / genetics*
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Viral Proteins / metabolism
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Virus Replication / drug effects
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Zidovudine / administration & dosage
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Zidovudine / therapeutic use
Substances
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Antiviral Agents
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Viral Proteins
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Zidovudine
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Interferons
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Arsenic