The female Drosophila reproductive organ, the ovary, has provided researchers with an incisive genetic system with which principle regulation of stem cell maintenance and differentiation has been delineated. An environmental niche regulates a stem cell's asymmetric self-renewal division that produces a daughter stem cell and a differentiated daughter cell, which further differentiate into eggs. A number of extrinsic and intrinsic factors have been identified that are required either for stem cell maintenance or differentiation. Bam/Bgcn complex plays a pivotal role in promoting stem cell differentiation. Recent papers suggest that Bam/Bgcn complex regulates translation of important maintenance factors and is also involved in the regulation of microRNA-dependent translational repression. Here, we focus on Bam and Bgcn repression of stem cell maintenance factors in the differentiation of germline stem cells (GSCs).
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