New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942: II. structure elucidation

Narihiro Ugaki; Hiroyuki Yamazaki; Ryuji Uchida; Hiroshi Tomoda

doi:10.1038/ja.2011.106

New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942: II. structure elucidation

J Antibiot (Tokyo). 2012 Jan;65(1):21-4. doi: 10.1038/ja.2011.106. Epub 2011 Nov 30.

Authors

Narihiro Ugaki¹, Hiroyuki Yamazaki, Ryuji Uchida, Hiroshi Tomoda

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.

PMID: 22126896
DOI: 10.1038/ja.2011.106

Abstract

The structure of a new congener of chaetochromin, an inhibitor of triacylglycerol synthesis in CHO-K1 cells produced by Penicillium sp. FKI-4942, was elucidated by spectroscopic methods, including various NMR experiments. Isochaetochromin A(1) has a bis-naphtho-γ-pyrone moiety.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Models, Molecular
Naphthols / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Penicillium / chemistry*
Pyrones / chemistry*
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Naphthols
Pyrones