The interaction enthalpy of amide solvents with single-walled carbon nanotube (SWCNT) dispersions is measured using isothermal titration calorimetry (ITC). N,N-Dimethyl-formamide (DMF) and N-methyl-2-pyrilidone (NMP) were used to make dispersions of highly purified (6,5) SWCNTs. Using isothermal titration calorimetry, the ΔH and K(A) terms related to the solvent-nanotube interactions were measured, and ΔG and ΔS of the interaction were determined. It was found that the interaction enthalpy of NMP with SWCNTs dispersed in DMF was exothermic. The addition of a second solvent into a NMP or DMF dispersion produced spontaneous exfoliation of SWCNT bundles as the solvent properties became more favorable. During the titration, a positive change in interaction entropy within the dispersed system due to the unbundling of SWCNTs was measured. From blank titrations of pure DMF into pure NMP and the reverse, dilution enthalpies were also calculated and compared to the literature, along with the corresponding enthalpic interaction coefficients, h(xx) and h(xxx). From our results, ITC appears to be a viable technique for measuring the interaction of solvent molecules with the surface of SWCNTs and for measuring the effect of mixed solvent properties on SWCNT dispersions.