[The relationship between CD44 and immune escape in gastric carcinoma]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Sep;27(9):1023-4.
[Article in Chinese]

Abstract

Aim: To study the relationship between CD44 and gastric carcinoma cells.

Methods: The rate and mean fluorecence intension of CD44 cells were detected by flow cytometry.

Results: The rate of CD44' cells was 93.46 ± 3.13% in gastric carcinoma which is higher than 21.27 ± 9. 59% in normal gastric mucosa ( P < 0. 05); The mean fluorecence intension of CD44 in gastric carcinoma was 175. 58 + 49. 21 which was no difference to 141. 02 ± 113.44 in normal gastric mucosa ( P > 0. 05).

Conclusions: In gastric carcinoma, The increasing of CD44 protein indicated that it may play an important role in the occurrence, development and metabasis of gastric cancer.

MeSH terms

  • Adult
  • Aged
  • Female
  • Flow Cytometry
  • Humans
  • Hyaluronan Receptors / metabolism*
  • Male
  • Middle Aged
  • Stomach Neoplasms / immunology*
  • Stomach Neoplasms / metabolism
  • Tumor Escape*

Substances

  • Hyaluronan Receptors