Abstract
Pseudomonas aeruginosa possesses complex regulatory networks controlling virulence and survival under adverse conditions, including antibiotic pressure, which are interconnected and share common regulatory proteins. Here, we screen a panel of 13 mutants defective in intracellular proteases and demonstrate that, in addition to the known alterations in Lon and AsrA mutants, mutation of three protease-related proteins PfpI, ClpS, and ClpP differentially affected antibiotic resistance, swarming motility, and biofilm formation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins
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Biofilms / drug effects*
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Biofilms / growth & development
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Drug Resistance, Bacterial / drug effects*
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Endopeptidases / genetics
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Endopeptidases / metabolism*
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Endopeptidases / pharmacology
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Gene Expression Regulation, Bacterial
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Humans
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Microbial Sensitivity Tests
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Movement / drug effects*
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Mutation
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / enzymology*
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Pseudomonas aeruginosa / growth & development
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Pseudomonas aeruginosa / physiology
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Virulence
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Endopeptidases