The level of native and oxidized lipoprotein(a) in children with nephrotic syndrome

Clin Biochem. 2012 Jan;45(1-2):101-5. doi: 10.1016/j.clinbiochem.2011.11.002. Epub 2011 Nov 19.

Abstract

Objective: To investigate lipoprotein(a) [Lp(a)], oxidized Lp(a) [ox-Lp(a)] and Lp(a) immune complex [Lp(a)-IC] levels in children with nephrotic syndrome (NS).

Design and methods: Plasma Lp(a), ox-Lp(a) and Lp(a)-IC levels were determined in 106 NS children in acute-period, 42 in remission and 155 controls.

Results: Lp(a) and ox-Lp(a) levels were significantly higher in acute-period and remission NS than in control. Ox-Lp(a) levels in acute-period NS were higher than in remission. Lp(a)-IC levels in acute-period NS were higher than in control. Lp(a), ox-Lp(a) and Lp(a)-IC were found negatively related with albumin in NS. Lp(a), ox-Lp(a) and Lp(a)-IC levels decreased after use of steroid therapy. Multiple linear regression analysis found relative change of albumin, creatinine, urea, triglyceride and high density lipoprotein cholesterol accounted for 78.9% of variation in ox-Lp(a).

Conclusions: Lp(a), ox-Lp(a) and Lp(a)-IC levels were increased in NS children, which may play an important role in the processes of atherosclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albumins / metabolism
  • Atherosclerosis
  • Child, Preschool
  • Female
  • Humans
  • Immune System
  • Infant
  • Kidney / metabolism
  • Lipids / chemistry
  • Lipoprotein(a) / metabolism*
  • Male
  • Nephrotic Syndrome / blood
  • Nephrotic Syndrome / metabolism*
  • Oxidative Stress
  • Oxygen / chemistry*
  • Regression Analysis
  • Remission Induction

Substances

  • Albumins
  • Lipids
  • Lipoprotein(a)
  • Oxygen