Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines

Carla S Francisco; Lígia R Rodrigues; Nuno M F S A Cerqueira; Ana M F Oliveira-Campos; Lígia M Rodrigues

doi:10.1016/j.ejmech.2011.11.005

Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines

Eur J Med Chem. 2012 Jan;47(1):370-6. doi: 10.1016/j.ejmech.2011.11.005. Epub 2011 Nov 12.

Authors

Carla S Francisco¹, Lígia R Rodrigues, Nuno M F S A Cerqueira, Ana M F Oliveira-Campos, Lígia M Rodrigues

Affiliation

¹ Chemistry Centre, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

PMID: 22119152
DOI: 10.1016/j.ejmech.2011.11.005

Abstract

The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumor cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma) were evaluated, and discussed in terms of structure-activity relationship.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Coumarins / chemical synthesis*
Coumarins / chemistry
Coumarins / pharmacology*
Humans
Models, Molecular
Molecular Conformation
Structure-Activity Relationship

Substances

Antineoplastic Agents
Coumarins