Abstract
Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreobeiline (9), β-amyrone (10), and (S)-3-methoxynordomesticine (11). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid, N-dimethylphyllocryptine (12). Structures of compounds 1-12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-α-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1-12 exhibited strong to moderate bioactivities in aforementioned bioassays.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / drug effects
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Aporphines / chemistry
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Aporphines / isolation & purification
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Aporphines / pharmacology*
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Biological Assay
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Candida albicans / drug effects
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Cholinesterase Inhibitors
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Glycoside Hydrolase Inhibitors
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Lauraceae / chemistry*
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Leishmania / drug effects*
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Leishmaniasis / parasitology
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Molecular Structure
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
Substances
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2-hydroxy-9-methoxyaporphine
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Alkaloids
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Antifungal Agents
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Aporphines
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Cholinesterase Inhibitors
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Glycoside Hydrolase Inhibitors
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Plant Extracts
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aporphine
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Acetylcholinesterase