Abstract
A new iridoid, jatamandoid A (1), and four known analogues (2-5) were isolated from the roots of Valeriana jatamansi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). Five compounds were evaluated and compounds 1, 2 and 5 showed moderate neuroprotective effects against MPP(+)-induced neuronal SH-SY5Y cell death.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Death / drug effects
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Cell Line / drug effects
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Drug Evaluation, Preclinical
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Humans
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Iridoids / analysis
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Iridoids / chemistry*
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Iridoids / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology*
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Plant Roots / chemistry
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Spectrometry, Mass, Electrospray Ionization / methods
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Valerian / chemistry*
Substances
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Iridoids
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Neuroprotective Agents
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jatamandoid A