The impact of the dibutyrylchitin molar mass on the bioactive properties of dressings used to treat soft tissue wounds

J Biomed Mater Res B Appl Biomater. 2012 Jan;100(1):11-22. doi: 10.1002/jbm.b.31895. Epub 2011 Nov 24.

Abstract

In this work, we describe a novel technique for producing biocompatible medical products with bioactive properties from the biodegradable polymer dibutyrylchitin (DBC). Materials produced by blowing out polymer solutions have excellent hemostaic properties and are easy to handle during surgery. Biocompatibility studies, encompassing hemostasis and the evaluation of post-implantation reactions, indicate that the biological properties of DBC depend on the molecular mass of the polymer. Lower molecular mass polymers are preferable for use in implanted wound dressings.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorbable Implants*
  • Animals
  • Biological Dressings*
  • Chitin / analogs & derivatives*
  • Hemostasis, Surgical / methods
  • Hemostatics*
  • Humans
  • Male
  • Materials Testing / methods*
  • Rats
  • Rats, Wistar
  • Wounds and Injuries / therapy*

Substances

  • Hemostatics
  • di-O-butyrylchitin
  • Chitin