A concise asymmetric synthesis of (-)-rasfonin

Yange Huang; Adriaan J Minnaard; Ben L Feringa

doi:10.1039/c1ob06700a

A concise asymmetric synthesis of (-)-rasfonin

Org Biomol Chem. 2012 Jan 7;10(1):29-31. doi: 10.1039/c1ob06700a. Epub 2011 Nov 24.

Authors

Yange Huang¹, Adriaan J Minnaard, Ben L Feringa

Affiliation

¹ Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

PMID: 22113704
DOI: 10.1039/c1ob06700a

Abstract

A very efficient total synthesis of the apoptosis inducer (-)-rasfonin has been developed using CuBr/JosiPhos catalyzed iterative asymmetric conjugate addition of MeMgBr and Feringa's butenolide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects
Fatty Acids, Unsaturated / chemical synthesis*
Fatty Acids, Unsaturated / chemistry
Fatty Acids, Unsaturated / pharmacology
Pyrones / chemical synthesis*
Pyrones / chemistry
Pyrones / pharmacology

Substances

Fatty Acids, Unsaturated
Pyrones
rasfonin