Abstract
Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH(2)Cl(2) extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2-4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Annona / chemistry*
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Aporphines / isolation & purification
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Aporphines / pharmacology*
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Carbolines / isolation & purification
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Carbolines / pharmacology*
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Inhibitory Concentration 50
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Mice
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Stems / chemistry*
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Pyrimidines / isolation & purification
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Pyrimidines / pharmacology*
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Trypanocidal Agents / isolation & purification
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Trypanocidal Agents / pharmacology*
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Trypanosoma cruzi / drug effects
Substances
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Aporphines
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Carbolines
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O-methylmoschatoline
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Plant Extracts
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Pyrimidines
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Trypanocidal Agents
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annomontine
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liriodenine