SV119-gold nanocage conjugates: a new platform for targeting cancer cells via sigma-2 receptors

Nanoscale. 2012 Jan 21;4(2):421-4. doi: 10.1039/c1nr11469g. Epub 2011 Nov 24.

Abstract

We have functionalized the surface of gold nanocages with SV119, a synthetic small molecule specific to sigma-2 receptors, and then demonstrated the capability of this new class of conjugates for targeting cancer cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Gold / chemistry*
  • Humans
  • Materials Testing
  • Nanocapsules / chemistry*
  • Nanocapsules / ultrastructure
  • Nanomedicine / methods*
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Neoplasms, Experimental / chemistry*
  • Neoplasms, Experimental / metabolism*
  • Neoplasms, Experimental / pathology
  • Particle Size
  • Receptors, sigma / metabolism*

Substances

  • Nanocapsules
  • Receptors, sigma
  • sigma-2 receptor
  • Gold