Enantioselective synthesis of branched allylic esters via rhodium-catalyzed coupling of allenes with carboxylic acids

Philipp Koschker; Alexandre Lumbroso; Bernhard Breit

doi:10.1021/ja210149g

Enantioselective synthesis of branched allylic esters via rhodium-catalyzed coupling of allenes with carboxylic acids

J Am Chem Soc. 2011 Dec 28;133(51):20746-9. doi: 10.1021/ja210149g. Epub 2011 Dec 1.

Authors

Philipp Koschker¹, Alexandre Lumbroso, Bernhard Breit

Affiliation

¹ Institut für Organische Chemie und Biochemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg im Breisgau, Germany.

PMID: 22111875
DOI: 10.1021/ja210149g

Abstract

We report on the first intermolecular asymmetric catalytic regio- and enantioselective addition of carboxylic acids to terminal allenes to form valuable branched allylic esters, employing a rhodium(I)/(R,R)-DIOP catalyst system.