Synthesis of novel lidocaine-releasing poly(diol-co-citrate) elastomers by using deep eutectic solvents

Chem Commun (Camb). 2012 Jan 14;48(4):579-81. doi: 10.1039/c1cc15284j. Epub 2011 Nov 22.

Abstract

Poly(octanediol-co-citrate) elastomers containing high loading of lidocaine were synthesized at temperatures below 100 °C by means of using deep eutectic mixtures of 1,8-octanediol and lidocaine. The preservation of lidocaine integrity resulted in high-capacity drug-eluting elastomers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthetics, Local / administration & dosage*
  • Chemistry Techniques, Synthetic
  • Citrates / chemical synthesis
  • Citrates / chemistry*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Elastomers / chemical synthesis
  • Elastomers / chemistry*
  • Hot Temperature
  • Lidocaine / administration & dosage*
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Solvents / chemistry

Substances

  • Anesthetics, Local
  • Citrates
  • Drug Carriers
  • Elastomers
  • Polymers
  • Solvents
  • poly(1,8-octanediol citrate)
  • Lidocaine