A novel DNA-templated click chemistry strategy for fluorescent detection of copper(II) ions

Chem Commun (Camb). 2012 Jan 7;48(2):281-3. doi: 10.1039/c1cc16049d. Epub 2011 Nov 22.

Abstract

A novel fluorescent strategy has been developed for sensitive turn-on detection of Cu(2+) based on high efficiency of DNA-templated organic synthesis, great specificity of alkyne-azide click reaction to the catalysis of copper ions and the sequential strand displacement for signal transduction.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry
  • Azides / chemistry
  • Catalysis
  • Cations, Divalent / analysis*
  • Click Chemistry / methods*
  • Copper / analysis*
  • DNA / chemistry*
  • Sensitivity and Specificity
  • Spectrometry, Fluorescence / methods*

Substances

  • Alkynes
  • Azides
  • Cations, Divalent
  • Copper
  • DNA