Abstract
Ethnopharmacological relevance:
Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness.
Aim of the study:
The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT).
Materials and methods:
The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice.
Results:
In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway.
Conclusions:
It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Blood Glucose / analysis
-
Blood Urea Nitrogen
-
Creatinine / blood
-
Diet, High-Fat
-
Disease Models, Animal
-
Drugs, Chinese Herbal / pharmacology
-
Drugs, Chinese Herbal / therapeutic use*
-
Ferns*
-
Hyperlipidemias / drug therapy*
-
Hyperlipidemias / etiology
-
Hyperlipidemias / metabolism
-
Kidney / drug effects
-
Kidney / metabolism
-
Lipid Peroxidation / drug effects
-
Lipids / blood
-
Male
-
Mice
-
Nephrotic Syndrome / chemically induced
-
Nephrotic Syndrome / drug therapy*
-
Nephrotic Syndrome / metabolism
-
Nitric Oxide / blood
-
Nitric Oxide Synthase Type II / blood
-
Oxidative Stress / drug effects
-
Phytotherapy
-
Polyphenols / pharmacology
-
Polyphenols / therapeutic use*
-
Potassium Dichromate
-
Protective Agents / pharmacology
-
Protective Agents / therapeutic use*
-
Puromycin Aminonucleoside
-
Vascular Endothelial Growth Factor A / blood
-
Vascular Endothelial Growth Factor A / metabolism
Substances
-
Blood Glucose
-
Drugs, Chinese Herbal
-
Lipids
-
Polyphenols
-
Protective Agents
-
Vascular Endothelial Growth Factor A
-
vascular endothelial growth factor A, mouse
-
Nitric Oxide
-
Puromycin Aminonucleoside
-
Creatinine
-
Nitric Oxide Synthase Type II
-
Nos2 protein, mouse
-
Potassium Dichromate