Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

J Ethnopharmacol. 2012 Jan 6;139(1):207-13. doi: 10.1016/j.jep.2011.11.002. Epub 2011 Nov 10.

Abstract

Ethnopharmacological relevance: Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness.

Aim of the study: The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT).

Materials and methods: The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice.

Results: In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway.

Conclusions: It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Blood Urea Nitrogen
  • Creatinine / blood
  • Diet, High-Fat
  • Disease Models, Animal
  • Drugs, Chinese Herbal / pharmacology
  • Drugs, Chinese Herbal / therapeutic use*
  • Ferns*
  • Hyperlipidemias / drug therapy*
  • Hyperlipidemias / etiology
  • Hyperlipidemias / metabolism
  • Kidney / drug effects
  • Kidney / metabolism
  • Lipid Peroxidation / drug effects
  • Lipids / blood
  • Male
  • Mice
  • Nephrotic Syndrome / chemically induced
  • Nephrotic Syndrome / drug therapy*
  • Nephrotic Syndrome / metabolism
  • Nitric Oxide / blood
  • Nitric Oxide Synthase Type II / blood
  • Oxidative Stress / drug effects
  • Phytotherapy
  • Polyphenols / pharmacology
  • Polyphenols / therapeutic use*
  • Potassium Dichromate
  • Protective Agents / pharmacology
  • Protective Agents / therapeutic use*
  • Puromycin Aminonucleoside
  • Vascular Endothelial Growth Factor A / blood
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Blood Glucose
  • Drugs, Chinese Herbal
  • Lipids
  • Polyphenols
  • Protective Agents
  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, mouse
  • Nitric Oxide
  • Puromycin Aminonucleoside
  • Creatinine
  • Nitric Oxide Synthase Type II
  • Nos2 protein, mouse
  • Potassium Dichromate