Analysing the composition of outpatient antibiotic use: a tutorial on compositional data analysis

Christel Faes; Geert Molenberghs; Niel Hens; Arno Muller; Herman Goossens; Samuel Coenen

doi:10.1093/jac/dkr461

Analysing the composition of outpatient antibiotic use: a tutorial on compositional data analysis

J Antimicrob Chemother. 2011 Dec:66 Suppl 6:vi89-94. doi: 10.1093/jac/dkr461.

Authors

Christel Faes¹, Geert Molenberghs, Niel Hens, Arno Muller, Herman Goossens, Samuel Coenen

Affiliation

¹ Interuniversity Institute for Biostatistics and Statistical Bioinformatics, University of Hasselt, Hasselt, Belgium. christel.faes@uhasselt.be

PMID: 22096070
DOI: 10.1093/jac/dkr461

Abstract

In this tutorial, statistical methods for studying outpatient use of antibiotics in Europe are described, using data provided by IMS Health. The methods are applied to two related research questions, namely the assessment of changes in the relative volume of use of different antibiotic subclasses over time and changes in the absolute volume of antibiotic use.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ambulatory Care / statistics & numerical data
Anti-Bacterial Agents / therapeutic use
Cephalosporins / therapeutic use
Computational Biology / methods
Data Interpretation, Statistical*
Drug Prescriptions / statistics & numerical data
Drug Utilization / statistics & numerical data*
Drug Utilization / trends
Geography
Humans
Outpatients / statistics & numerical data*
Penicillins / therapeutic use
Tetracycline / therapeutic use

Substances

Anti-Bacterial Agents
Cephalosporins
Penicillins
Tetracycline