Collaboration between PcG proteins and MLL fusions in Leukemogenesis: an emerging paradigm

Bernd B Zeisig; Mari-Francis Arteaga; Cecile Thirant; Chi Wai Eric So

doi:10.1016/j.ccr.2011.10.031

Collaboration between PcG proteins and MLL fusions in Leukemogenesis: an emerging paradigm

Cancer Cell. 2011 Nov 15;20(5):551-3. doi: 10.1016/j.ccr.2011.10.031.

Authors

Bernd B Zeisig¹, Mari-Francis Arteaga, Cecile Thirant, Chi Wai Eric So

Affiliation

¹ Leukaemia and Stem Cell Biology Group, Department of Haematological Medicine, Rayne Institute, King's College London, SE5 9NU London, UK.

PMID: 22094247
DOI: 10.1016/j.ccr.2011.10.031

Abstract

PcG and TrxG proteins mostly with opposite transcriptional activities play key roles in normal and malignant development. In this issue of Cancer Cell, Tan et al. report an unexpected collaboration between CBX8 and MLL-AF9 in leukemia, revealing a far more complicated functional crosstalk between these master epigenetic regulators in oncogenesis.

Publication types

Comment
Research Support, Non-U.S. Gov't

Grants and funding

G0800892/MRC_/Medical Research Council/United Kingdom