Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia

Fitoterapia. 2012 Jan;83(1):223-9. doi: 10.1016/j.fitote.2011.10.019. Epub 2011 Nov 7.

Abstract

The galloylated cyanogenic glucosides based on prunasin (1-7), gallotannins (8-14), ellagitannins (15-17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H(2)O(2))-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Glucosides / chemistry
  • Glucosides / pharmacology*
  • Hydrogen Peroxide / toxicity
  • Hydrolyzable Tannins / chemistry
  • Hydrolyzable Tannins / pharmacology*
  • Mice
  • Molecular Structure
  • Neuroprotective Agents / pharmacology*

Substances

  • Glucosides
  • Hydrolyzable Tannins
  • Neuroprotective Agents
  • Hydrogen Peroxide