New flavanones from the leaves of Cryptocarya chinensis and their antituberculosis activity

Chem Biodivers. 2011 Nov;8(11):2015-24. doi: 10.1002/cbdv.201000367.

Abstract

Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses. Among the isolated compounds, pinocembrin (5) and cryptocaryone (6) exhibited antituberculosis activity against Mycobacterium tuberculosis H(37) Rv strain in vitro with MIC values of 3.5 and 25.0 μg/ml, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / isolation & purification*
  • Antitubercular Agents / pharmacology
  • Cryptocarya / chemistry*
  • Flavanones / isolation & purification*
  • Flavanones / pharmacology
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects*
  • Plant Leaves / chemistry
  • Pyrones / isolation & purification*
  • Pyrones / pharmacology

Substances

  • Antitubercular Agents
  • Flavanones
  • Pyrones
  • cryptocaryone
  • pinocembrin