Abstract
Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses. Among the isolated compounds, pinocembrin (5) and cryptocaryone (6) exhibited antituberculosis activity against Mycobacterium tuberculosis H(37) Rv strain in vitro with MIC values of 3.5 and 25.0 μg/ml, respectively.
Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology
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Cryptocarya / chemistry*
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Flavanones / isolation & purification*
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Flavanones / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Structure
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Mycobacterium tuberculosis / drug effects*
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Plant Leaves / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology
Substances
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Antitubercular Agents
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Flavanones
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Pyrones
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cryptocaryone
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pinocembrin