Multifunctional mesoporous composite nanocapsules for highly efficient MRI-guided high-intensity focused ultrasound cancer surgery

Yu Chen; Hangrong Chen; Yang Sun; Yuanyi Zheng; Deping Zeng; Faqi Li; Shengjian Zhang; Xia Wang; Kun Zhang; Ming Ma; Qianjun He; Linlin Zhang; Jianlin Shi

doi:10.1002/anie.201106180

Multifunctional mesoporous composite nanocapsules for highly efficient MRI-guided high-intensity focused ultrasound cancer surgery

Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12505-9. doi: 10.1002/anie.201106180. Epub 2011 Nov 10.

Authors

Yu Chen¹, Hangrong Chen, Yang Sun, Yuanyi Zheng, Deping Zeng, Faqi Li, Shengjian Zhang, Xia Wang, Kun Zhang, Ming Ma, Qianjun He, Linlin Zhang, Jianlin Shi

Affiliation

¹ State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

PMID: 22076783
DOI: 10.1002/anie.201106180

Abstract

Bloodless surgical knife: Nano-biotechnology has been introduced into imaging-guided high-intensity focused ultrasound (HIFU) cancer surgery by adopting engineered multifunctional manganese-based mesoporous composite nanocapsules as the contrast agents for T(1)-weighted magnetic resonance imaging (MRI) and simultaneously as synergistic agents for MRI-guided HIFU cancer surgery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Liver Neoplasms / pathology
Liver Neoplasms / surgery*
Liver Neoplasms / therapy*
Magnetic Resonance Imaging / methods*
Nanocapsules / chemistry*
Particle Size
Porosity
Rabbits
Surface Properties
Ultrasonic Therapy*

Substances

Nanocapsules