Increased risk of brain injury in IVF babies

Minerva Pediatr. 2011 Dec;63(6):445-8.

Abstract

Aim: The aim of this paper was to assess brain injury occurrence among in vitro fertilization (IVF) babies.

Methods: We examined all babies born in our hospital in the triennium 2004-2006, comparing the presence of brain injuries between IVF babies and the rest of the population.

Results: In IVF group (180 babies), brain injury was present in 4 babies, while in the rest of population (n=3602) it was present in 23 babies (P=0.042, RR: 3.18). IVF babies have a higher risk of being born with a birthweight less than 2 500 grams (P<0.0001; RR: 5.133). When we considered only babies born with a birth weight less than 2 500 grams, the difference of brain injury between the two groups was not significant.

Conclusion: In IVF babies, brain injury occurred more frequently than in the rest of population. This is probably due to a higher rate of premature births and low birth weight in IVF population. Anyway, this data should be disclosed to future parents to make an informed decision.

Publication types

  • Comparative Study

MeSH terms

  • Brain Injuries / epidemiology
  • Brain Injuries / etiology*
  • Female
  • Fertilization in Vitro / adverse effects*
  • Humans
  • Incidence
  • Infant
  • Infant, Low Birth Weight*
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / epidemiology
  • Infant, Premature, Diseases / etiology*
  • Italy / epidemiology
  • Male
  • Pregnancy
  • Premature Birth / etiology*
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors