Isolation and characterization of beta-hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I in the urine of a patient with congenital erythropoietic porphyria by high performance liquid chromatography and liquid secondary ion mass spectrometry

R Guo; W Chai; J M Rideout; A M Lawson; C K Lim

doi:10.1002/bmc.1130040404

Isolation and characterization of beta-hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I in the urine of a patient with congenital erythropoietic porphyria by high performance liquid chromatography and liquid secondary ion mass spectrometry

Biomed Chromatogr. 1990 Jul;4(4):141-3. doi: 10.1002/bmc.1130040404.

Authors

R Guo¹, W Chai, J M Rideout, A M Lawson, C K Lim

Affiliation

¹ Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, UK.

PMID: 2207373
DOI: 10.1002/bmc.1130040404

Abstract

beta-Hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I have been isolated from the urine of a patient with congenital erythropoietic porphyria by reversed phase high performance liquid chromatography. The compounds were characterized by their chemical behaviour and confirmed by liquid secondary ion mass spectrometry.

MeSH terms

Adult
Chromatography, High Pressure Liquid
Erythropoiesis
Glycolates / urine*
Humans
Lactates / urine*
Lactic Acid* / analogs & derivatives*
Male
Mass Spectrometry
Porphyrias / blood
Porphyrias / congenital
Porphyrias / urine*
Uroporphyrins / urine*

Substances

Glycolates
Lactates
Uroporphyrins
glycolic acid
Lactic Acid
uroporphyrin I
hydracrylic acid