Abstract
Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
Keywords:
anticancer agents; cell regulation; marine natural products; marine sponges; protein kinase inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Cyclin-Dependent Kinases / chemistry
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Cyclin-Dependent Kinases / isolation & purification
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Cyclin-Dependent Kinases / pharmacology
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ErbB Receptors / antagonists & inhibitors
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Glycogen Synthase Kinase 3 / antagonists & inhibitors
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Mitogen-Activated Protein Kinases / antagonists & inhibitors
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Porifera / chemistry*
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Protein Kinase C / antagonists & inhibitors
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / isolation & purification*
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Protein Kinase Inhibitors / pharmacology
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Protein-Tyrosine Kinases / antagonists & inhibitors
Substances
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Biological Products
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Protein Kinase Inhibitors
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ErbB Receptors
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Protein-Tyrosine Kinases
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Protein Kinase C
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Cyclin-Dependent Kinases
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Mitogen-Activated Protein Kinases
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Glycogen Synthase Kinase 3