The potential of antimicrobial peptides as biocides

Int J Mol Sci. 2011;12(10):6566-96. doi: 10.3390/ijms12106566. Epub 2011 Oct 6.

Abstract

Antimicrobial peptides constitute a diverse class of naturally occurring antimicrobial molecules which have activity against a wide range of pathogenic microorganisms. Antimicrobial peptides are exciting leads in the development of novel biocidal agents at a time when classical antibiotics are under intense pressure from emerging resistance, and the global industry in antibiotic research and development stagnates. This review will examine the potential of antimicrobial peptides, both natural and synthetic, as novel biocidal agents in the battle against multi-drug resistant pathogen infections.

Keywords: antimicrobial; biocides; peptides.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antimicrobial Cationic Peptides / chemistry*
  • Antimicrobial Cationic Peptides / metabolism
  • Antimicrobial Cationic Peptides / pharmacology
  • Bacteria / metabolism
  • Cell Membrane / metabolism
  • Cell Wall / metabolism
  • Disinfectants / chemistry*
  • Disinfectants / metabolism
  • Disinfectants / pharmacology
  • Drug Design
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Hemolysis / drug effects
  • Lipopeptides / chemistry
  • Lipopeptides / pharmacology

Substances

  • Antimicrobial Cationic Peptides
  • Disinfectants
  • Lipopeptides