Indaziflam, a new alkylazine herbicide that inhibits cellulose biosynthesis, is under current development for soil applications in perennial crops and nonagricultural areas. Sorption and desorption of indaziflam in six soils from Brazil and three soils from the United States, with different physical chemical properties, were investigated using the batch equilibration method. Sorption kinetics demonstrated that soil-solution equilibrium was attained in <24 h. The Freundlich equation described the sorption behavior of the herbicide for all soils (R(2) > 0.99). K(f) values of the Brazilian oxisols ranged from 4.66 to 29.3, and 1/n values were ≥ 0.95. Sorption was positively correlated to %OC and clay contents. U.S. mollisol K(f) values ranged from 6.62 to 14.3; 1/n values for sorption were ≥ 0.92. K(f) values from mollisols were also positively correlated with %OC. These results suggest that indaziflam potential mobility, based solely on its sorption coefficients, would range from moderate to low in soil. Desorption was hysteretic on all soils, further decreasing its potential mobility for offsite transport.