Chemical and metabolic aspects of antimetabolite toxins produced by Pseudomonas syringae pathovars

Toxins (Basel). 2011 Sep;3(9):1089-110. doi: 10.3390/toxins3091089. Epub 2011 Aug 31.

Abstract

Pseudomonas syringae is a phytopathogenic bacterium present in a wide variety of host plants where it causes diseases with economic impact. The symptoms produced by Pseudomonas syringae include chlorosis and necrosis of plant tissues, which are caused, in part, by antimetabolite toxins. This category of toxins, which includes tabtoxin, phaseolotoxin and mangotoxin, is produced by different pathovars of Pseudomonas syringae. These toxins are small peptidic molecules that target enzymes of amino acids' biosynthetic pathways, inhibiting their activity and interfering in the general nitrogen metabolism. A general overview of the toxins' chemistry, biosynthesis, activity, virulence and potential applications will be reviewed in this work.

Keywords: arginine; glutamine; mangotoxin; ornithine; phaseolotoxin; tabtoxin; virulence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antimetabolites / chemistry
  • Antimetabolites / metabolism*
  • Antimetabolites / toxicity
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism*
  • Bacterial Proteins / toxicity
  • Bacterial Toxins / chemistry
  • Bacterial Toxins / metabolism*
  • Bacterial Toxins / toxicity
  • Biological Assay
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / toxicity
  • Pseudomonas syringae / metabolism*

Substances

  • Antimetabolites
  • Bacterial Proteins
  • Bacterial Toxins
  • Enzyme Inhibitors