NetB, a pore-forming toxin from necrotic enteritis strains of Clostridium perfringens

Anthony L Keyburn; Trudi L Bannam; Robert J Moore; Julian I Rood

doi:10.3390/toxins2071913

NetB, a pore-forming toxin from necrotic enteritis strains of Clostridium perfringens

Toxins (Basel). 2010 Jul;2(7):1913-27. doi: 10.3390/toxins2071913. Epub 2010 Jul 23.

Authors

Anthony L Keyburn¹, Trudi L Bannam, Robert J Moore, Julian I Rood

Affiliation

¹ CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia. Anthony. Keyburn@csiro.au

Abstract

The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.

Keywords: NetB; Clostridium perfringens; necrotic enteritis; pore-forming toxin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacterial Toxins / genetics
Bacterial Toxins / immunology
Bacterial Toxins / toxicity*
Bacterial Vaccines
Clostridium perfringens / pathogenicity
Enteritis / etiology*
Humans
Necrosis / etiology*

Substances

Bacterial Toxins
Bacterial Vaccines
NE B-like toxin, Clostridium perfringens