Ochratoxin A in ruminants−A review on its degradation by gut microbes and effects on animals

Toxins (Basel). 2010 Apr;2(4):809-39. doi: 10.3390/toxins2040809. Epub 2010 Apr 21.

Abstract

Ruminants are much less sensitive to ochratoxin A (OTA) than non-ruminants. The ruminal microbes, with protozoa being a central group, degrade the mycotoxin extensively, with disappearance half lives of 0.6-3.8 h. However, in some studies OTA was detected systemically when using sensitive analytical methods, probably due to some rumen bypass at proportions of estimated 2-6.5% of dosage (maximum 10%). High concentrate proportions and high feeding levels are dietary factors promoting the likeliness of systemic occurrence due to factors like shifts in microbial population and higher contamination potential. Among risk scenarios for ruminants, chronic intoxication represents the most relevant.

Keywords: mycotoxin; OTA; carry over; diet; enzymatic degradation; milk; protozoa.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animal Feed / analysis
  • Animals
  • Bacteria / metabolism*
  • Diet
  • Food Contamination / analysis
  • Milk / metabolism
  • Mycotoxins / metabolism*
  • Mycotoxins / toxicity
  • Ochratoxins / analysis
  • Ochratoxins / metabolism*
  • Ochratoxins / toxicity
  • Rumen / microbiology*
  • Ruminants

Substances

  • Mycotoxins
  • Ochratoxins
  • ochratoxin A