Dentists need to be able to give people with HIV/AIDS compassionate and comprehensive care. Previous studies have shown that many dental students have negative attitudes towards treating such individuals. This article addresses the effectiveness of a program that trains dental students in the issues of treating this population. All predoctoral students at the Loma Linda University School of Dentistry are required to receive this training. Students complete a pre-session survey during their third year and a post-session survey as they complete the training during their fourth year. The survey was administered from 2003 to 2009 during which 386 students completed responses to the post-session survey. Five questions in the survey address self-evaluation of knowledge, attitudes, and confidence in the efficacy of universal precautions and post-exposure prophylaxis following bloodborne exposures. This study reports on five two-year testing cycles and shows significant shifts in all five areas surveyed. The most significant gains were in the two areas that are not addressed in much detail in other courses in the dental school curriculum. These are familiarity with post-exposure prophylaxis (PEP) and confidence in the efficacy of PEP. These data support the usefulness of such a program in preparing future dentists to deliver appropriate care to persons living with HIV/AIDS.