Abstract
A triple α1,3 glucan synthase mutant of Aspergillus fumigatus obtained by successive deletions of the three α1,3 glucan synthase genes (AGS1, AGS2, and AGS3) has a cell wall devoid of α1,3 glucans. The lack of α1,3 glucans affects neither conidial germination nor mycelial vegetative growth and is compensated by an increase in β1,3 glucan and/or chitin content.
MeSH terms
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Aspergillus fumigatus / enzymology
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Aspergillus fumigatus / genetics
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Aspergillus fumigatus / physiology*
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Cell Wall / metabolism
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Chitin / metabolism
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Fungal Proteins / genetics*
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Gene Knockout Techniques
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Genetic Engineering
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Glucans / metabolism*
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Glucosyltransferases / genetics*
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Microbial Viability
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Mycelium / enzymology
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Mycelium / genetics
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Mycelium / physiology
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Phenotype
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Spores, Fungal / enzymology
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Spores, Fungal / genetics
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Spores, Fungal / physiology
Substances
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Fungal Proteins
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Glucans
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Chitin
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alpha-1,3-glucan
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1,4-glucan
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1,3-alpha-D-glucan synthase
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Glucosyltransferases