Abstract
Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipocytes / drug effects
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Adipocytes / enzymology
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Adipocytes / metabolism
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Animals
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Coordination Complexes / chemical synthesis*
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology
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Drug Stability
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Glycine / analogs & derivatives*
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Glycine / chemistry
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Hippurates / chemistry*
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Hydrogen-Ion Concentration
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Insulin / pharmacology*
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Models, Molecular
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Molecular Conformation
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Molecular Mimicry
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Phenols / chemistry*
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Phosphorylation
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Proto-Oncogene Proteins c-akt / metabolism
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Rats
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Salicylamides / chemistry*
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Vanadium / chemistry*
Substances
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Coordination Complexes
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Hippurates
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Hypoglycemic Agents
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Insulin
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N-(2-hydroxybenzyl)glycine
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Phenols
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Salicylamides
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Vanadium
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salicylurate
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Proto-Oncogene Proteins c-akt
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salicylamide
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Glycine