Diversity-oriented optical imaging probe development

Jun-Seok Lee; Marc Vendrell; Young-Tae Chang

doi:10.1016/j.cbpa.2011.10.007

Diversity-oriented optical imaging probe development

Curr Opin Chem Biol. 2011 Dec;15(6):760-7. doi: 10.1016/j.cbpa.2011.10.007. Epub 2011 Nov 4.

Authors

Jun-Seok Lee¹, Marc Vendrell, Young-Tae Chang

Affiliation

¹ Biomolecules Function Research Center, Future Convergence Research Division, Korea Institute of Science and Technology, 136-791, South Korea.

PMID: 22055497
DOI: 10.1016/j.cbpa.2011.10.007

Abstract

The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Combinatorial Chemistry Techniques
Fluorescent Dyes / analysis
Fluorescent Dyes / chemical synthesis*
Fluorescent Dyes / metabolism
Green Fluorescent Proteins / analysis
High-Throughput Screening Assays
Molecular Imaging / methods*
Molecular Probes / analysis
Molecular Probes / chemical synthesis*
Molecular Probes / metabolism
Staining and Labeling / methods*

Substances

Fluorescent Dyes
Molecular Probes
Green Fluorescent Proteins