Palladium-catalyzed direct olefination of urea derivatives with n-butyl acrylate by C-H bond activation under mild reaction conditions

Org Lett. 2011 Dec 2;13(23):6137-9. doi: 10.1021/ol202738j. Epub 2011 Nov 4.

Abstract

Pd(II)-catalyzed aromatic C-H bond activation using urea as a directing group was achieved in a p-TsOH/AcOH medium under mild reaction conditions. The direct olefination products of various urea derivatives were produced from aryl urea derivatives and butyl acrylate in moderate to good yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylates / chemistry*
  • Alkenes / chemistry*
  • Catalysis
  • Molecular Structure
  • Palladium / chemistry*
  • Urea / analogs & derivatives*
  • Urea / chemistry*

Substances

  • Acrylates
  • Alkenes
  • Palladium
  • n-butyl acrylate
  • Urea