Abstract
A dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children. Children on DRAAAS received 0.8-1.0 of artesunate/kg and 0.9-1.2 times amodiaquine/kg compared with those receiving SDRAA. Parasite and fever clearance and fall in hematocrit in the first 3 days were similar; both regimens were well tolerated. DRAAAS is simple and is efficacious.
Publication types
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Age Distribution
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Amodiaquine / administration & dosage*
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Amodiaquine / therapeutic use
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Antimalarials / administration & dosage*
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Antimalarials / therapeutic use
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Area Under Curve
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Arm
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Artemisinins / administration & dosage*
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Artemisinins / therapeutic use
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Artesunate
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Body Weight
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Child
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Child, Preschool
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Dose-Response Relationship, Drug
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Female
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Humans
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Malaria, Falciparum / diagnosis
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Malaria, Falciparum / drug therapy*
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Malaria, Falciparum / parasitology
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Male
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Plasmodium falciparum / isolation & purification
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Program Evaluation
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Treatment Outcome
Substances
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Antimalarials
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Artemisinins
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Amodiaquine
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Artesunate