A simple dose regimen of artesunate and amodiaquine based on arm span- or age range for childhood falciparum malaria: a preliminary evaluation

J Trop Pediatr. 2012 Aug;58(4):263-8. doi: 10.1093/tropej/fmr091. Epub 2011 Nov 3.

Abstract

A dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children. Children on DRAAAS received 0.8-1.0 of artesunate/kg and 0.9-1.2 times amodiaquine/kg compared with those receiving SDRAA. Parasite and fever clearance and fall in hematocrit in the first 3 days were similar; both regimens were well tolerated. DRAAAS is simple and is efficacious.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Age Distribution
  • Amodiaquine / administration & dosage*
  • Amodiaquine / therapeutic use
  • Antimalarials / administration & dosage*
  • Antimalarials / therapeutic use
  • Area Under Curve
  • Arm
  • Artemisinins / administration & dosage*
  • Artemisinins / therapeutic use
  • Artesunate
  • Body Weight
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Malaria, Falciparum / diagnosis
  • Malaria, Falciparum / drug therapy*
  • Malaria, Falciparum / parasitology
  • Male
  • Plasmodium falciparum / isolation & purification
  • Program Evaluation
  • Treatment Outcome

Substances

  • Antimalarials
  • Artemisinins
  • Amodiaquine
  • Artesunate