Abstract
Inflammation is an essential host defense system particularly in response to infection and injury; however, excessive or undesirable inflammatory responses contribute to acute and chronic human diseases. A high-throughput screening effort searching for anti-inflammatory compounds from medicinal plants deduced that the methanolic extract of Juniperus rigida S. et L. (Cupressaceae) inhibited significantly nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Activity-guided fractionation and isolation yielded 13 phenolic compounds, including one new phenylpropanoid glycosides, 3,4-dimethoxycinnamyl 9-O-β-D-glucopyranoside (1). Among the isolated compounds, phenylpropanoid glycosides with p-hydroxy group (2, 4) and massoniaside A (7), (+)-catechin (10), amentoflavone (11) effectively inhibited LPS-induced NO production in RAW264.7 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Benzofurans / isolation & purification
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Benzofurans / pharmacology
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Biflavonoids / isolation & purification
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Biflavonoids / pharmacology
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Catechin / isolation & purification
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Catechin / pharmacology
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Cell Line
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Cell Survival / drug effects
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Cinnamates / isolation & purification*
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Cinnamates / pharmacology
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Juniperus / chemistry*
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Lipopolysaccharides / pharmacology
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Macrophage Activation / drug effects
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Macrophages / drug effects
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Macrophages / metabolism
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Methanol
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Mice
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / biosynthesis
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Phenols / isolation & purification*
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Phenols / pharmacology
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Plant Extracts / chemistry*
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Plant Leaves / chemistry*
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Solvents
Substances
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3,4,9'-trihydroxy-3-methoxy-7,8-dihydrobenzofuran-1'-propanolneoligan-9-O-rhamnopyranoside
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3,4-dimethoxycinnamyl 9-O-beta-D-glucopyranoside
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Anti-Inflammatory Agents, Non-Steroidal
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Benzofurans
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Biflavonoids
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Cinnamates
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Glucosides
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Glycosides
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Lipopolysaccharides
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Phenols
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Plant Extracts
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Solvents
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Nitric Oxide
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Catechin
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amentoflavone
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Methanol