Practical approaches to effective management of intestinal radiation injury: benefit of resectional surgery

World J Gastroenterol. 2011 Sep 21;17(35):4013-6. doi: 10.3748/wjg.v17.i35.4013.

Abstract

Aim: To study the outcome of patients undergoing surgical resection of the bowel for sustained radiation-induced damage intractable to conservative management.

Methods: During a 7-year period we operated on 17 cases (5 male, 12 female) admitted to our surgical department with intestinal radiation injury (IRI). They were originally treated for a pelvic malignancy by surgical resection followed by postoperative radiotherapy. During follow-up, they developed radiation enteritis requiring surgical treatment due to failure of conservative management.

Results: IRI was located in the terminal ileum in 12 patients, in the rectum in 2 patients, in the descending colon in 2 patients, and in the cecum in one patient. All patients had resection of the affected region(s). There were no postoperative deaths, while 3 cases presented with postoperative complications (17.7%). All patients remained free of symptoms without evidence of recurrence of IRI for a median follow-up period of 42 mo (range, 6-96 mo).

Conclusion: We report a favorable outcome without IRI recurrence of 17 patients treated by resection of the diseased bowel segment.

Keywords: Bowel; Pelvic neoplasms; Radiation injuries; Surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Intestinal Neoplasms / radiotherapy*
  • Intestines / pathology*
  • Intestines / radiation effects*
  • Intestines / surgery*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Radiation Injuries / surgery*
  • Treatment Outcome