kConFab: a familial breast cancer consortium facilitating research and translational oncology

J Natl Cancer Inst Monogr. 2011;2011(43):79-81. doi: 10.1093/jncimonographs/lgr042.

Abstract

In 2005, 100,514 Australians were diagnosed with cancer, and over 10,000 of these cancers will be due to heritable causes. The impact of familial cancer by definition extends beyond the individual, affecting tens of thousands of parents, siblings, and children. The study of familial cancer causes has arguably made the greatest single contribution to our understanding of cancer biology. This knowledge is used clinically to guide investment in screening and prevention, as well as being translated into new treatments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Australia / epidemiology
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / genetics*
  • Clinical Trials as Topic / methods
  • Clinical Trials as Topic / trends
  • Female
  • Genes, BRCA1 / drug effects
  • Genes, BRCA2 / drug effects
  • Genetic Predisposition to Disease
  • Heterozygote
  • Humans
  • Medical Oncology* / methods
  • Medical Oncology* / organization & administration
  • Medical Oncology* / trends
  • Mutation
  • New Zealand / epidemiology
  • Patient Selection
  • Translational Research, Biomedical* / methods
  • Translational Research, Biomedical* / trends

Substances

  • Antineoplastic Agents