A new practical synthesis of triaryl and trisindolylmethanes under solvent-free reaction conditions

Org Biomol Chem. 2011 Dec 21;9(24):8393-9. doi: 10.1039/c1ob06280h. Epub 2011 Oct 31.

Abstract

An efficient and practical synthesis of triaryl and trisindolylmethanes is reported via the bisarylation of aryl aldehydes with activated arenes. The new method features mild solvent-free reaction conditions, in most cases nearly stoichiometric reagent ratios, catalytic amount of the readily available, easily-handled, recoverable and reusable Brønsted acid catalyst o-benzenedisulfonimide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Methane / analogs & derivatives
  • Methane / chemical synthesis*
  • Methane / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Methane