Abstract
Inflammation is a host adaptational response to cell injury caused by various exogenous and endogenous stimuli. IL-1β, which is an important proinflammatory cytokine secreted at the site of cellular injury, plays an important role in inflammation. Inflammasome is an intracellular multi-protein complex that mediates caspase-1-dependent processing of IL-1β. In this review, inflammasome function and its dysregulation are discussed in relation to autoinflammatory diseases.
MeSH terms
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Adaptor Proteins, Signal Transducing / physiology
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Apoptosis Regulatory Proteins / physiology
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CARD Signaling Adaptor Proteins / physiology
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Calcium-Binding Proteins / physiology
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Carrier Proteins / physiology
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Caspase 1 / physiology
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Cytoskeletal Proteins / physiology
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DNA-Binding Proteins
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Hereditary Autoinflammatory Diseases / etiology*
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Humans
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Inflammasomes / chemistry
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Inflammasomes / physiology*
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Inflammation Mediators
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Interleukin-1beta / metabolism*
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Interleukin-1beta / physiology
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Intracellular Signaling Peptides and Proteins / physiology
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLR Proteins
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Nuclear Proteins / physiology
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Pyrin
Substances
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AIM2 protein, human
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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CARD Signaling Adaptor Proteins
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Calcium-Binding Proteins
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Carrier Proteins
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Cytoskeletal Proteins
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DNA-Binding Proteins
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Inflammasomes
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Inflammation Mediators
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Interleukin-1beta
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Intracellular Signaling Peptides and Proteins
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLR Proteins
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NLRC4 protein, human
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NLRP1 protein, human
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NLRP3 protein, human
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NLRP6 protein, human
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Nuclear Proteins
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Pyrin
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Caspase 1