Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease

Curr Top Med Chem. 2011 Nov;11(22):2797-806. doi: 10.2174/156802611798184373.

Abstract

Multitarget agents directed at selected molecular targets involved in the pathogenic cascade of Alzheimer's disease (AD) have been increasingly sought after in recent years, with the aim of achieving enhanced therapeutic efficiency with respect to single-target drugs and drug candidates. At the same time, much attention has been devoted to identifying high quality pharmacological tools to help explore the molecular mechanisms underlying AD without being exposed to physicochemical challenges. Herein, we discuss several examples of both types of compounds, taken from our own research and derived from the leads memoquin, lipocrine and bis(7)tacrine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylcholinesterase / metabolism
  • Alkanes / chemistry
  • Alkanes / pharmacology*
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / enzymology
  • Amyloid beta-Peptides / antagonists & inhibitors
  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Ethylamines / chemistry
  • Ethylamines / pharmacology*
  • Humans
  • Ligands
  • Tacrine / analogs & derivatives*
  • Tacrine / chemistry
  • Tacrine / pharmacology
  • Thioctic Acid / analogs & derivatives*
  • Thioctic Acid / chemistry
  • Thioctic Acid / pharmacology

Substances

  • 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine
  • Alkanes
  • Amyloid beta-Peptides
  • Enzyme Inhibitors
  • Ethylamines
  • Ligands
  • lipocrine
  • memoquin
  • Tacrine
  • Thioctic Acid
  • Acetylcholinesterase