Non-classical structures among current platinum complexes with potential as antitumor drugs

Curr Top Med Chem. 2011;11(21):2613-22. doi: 10.2174/156802611798040723.

Abstract

The potential and limitations of the non classical metallodrugs with platinum as metal are discussed in this section, focusing not only in their design but in their mechanism of action and interaction with other biomolecules to introduce and encourage the readers on the potential of this field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / therapeutic use
  • Blood Proteins / metabolism
  • Cell Cycle Checkpoints / drug effects
  • Cell Line, Tumor
  • DNA / metabolism
  • Drug Design
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Organoplatinum Compounds / chemistry*
  • Organoplatinum Compounds / metabolism
  • Organoplatinum Compounds / therapeutic use
  • Platinum / chemistry*
  • Platinum / metabolism
  • Protein Binding / drug effects
  • Thiosemicarbazones / chemistry
  • Thiosemicarbazones / metabolism
  • Thiosemicarbazones / pharmacology

Substances

  • Antineoplastic Agents
  • Blood Proteins
  • Organoplatinum Compounds
  • Thiosemicarbazones
  • Platinum
  • DNA