Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis

Wim Declercq; Nozomi Takahashi; Peter Vandenabeele

doi:10.1016/j.immuni.2011.10.007

Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis

Immunity. 2011 Oct 28;35(4):493-5. doi: 10.1016/j.immuni.2011.10.007.

Authors

Wim Declercq¹, Nozomi Takahashi, Peter Vandenabeele

Affiliation

¹ Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, B-9052 Ghent, Belgium.

PMID: 22035842
DOI: 10.1016/j.immuni.2011.10.007

Abstract

In this issue of Immunity, Bonnet et al. (2011) show that skin-specific ablation of the adaptor protein FADD sensitizes keratinocytes to RIPK3-dependent necrotic cell death, which leads to severe skin inflammation.

Publication types

Comment