Transcriptional repressors: shutting off gene expression at the source affects developmental dynamics

Curr Biol. 2011 Oct 25;21(20):R859-60. doi: 10.1016/j.cub.2011.09.022.

Abstract

Developmental networks feature genes interlinked by transcriptional activation and repression. A new study indicates that repressors can 'shut the door' to newly initiating polymerases, allowing longer target genes to produce latent transcripts after shorter genes have been effectively silenced.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA Polymerase II / metabolism*
  • Drosophila / genetics*
  • Gene Expression Regulation, Developmental*
  • Repressor Proteins / physiology*
  • Transcription Factors / physiology*

Substances

  • Repressor Proteins
  • Transcription Factors
  • DNA Polymerase II