Biomimetic synthesis of chiral erbium-doped silver/peptide/silica core-shell nanoparticles (ESPN)

Nanoscale. 2011 Dec;3(12):5168-79. doi: 10.1039/c1nr10930h. Epub 2011 Oct 27.

Abstract

Peptide-modified silver nanoparticles have been coated with an erbium-doped silica layer using a method inspired by silica biomineralization. Electron microscopy and small-angle X-ray scattering confirm the presence of an Ag/peptide core and silica shell. The erbium is present as small Er(2)O(3) particles in and on the silica shell. Raman, IR, UV-Vis, and circular dichroism spectroscopies show that the peptide is still present after shell formation and the nanoparticles conserve a chiral plasmon resonance. Magnetic measurements find a paramagnetic behavior. In vitro tests using a macrophage cell line model show that the resulting multicomponent nanoparticles have a low toxicity for macrophages, even on partial dissolution of the silica shell.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials* / chemical synthesis
  • Biomimetic Materials* / chemistry
  • Biomimetic Materials* / pharmacokinetics
  • Biomimetic Materials* / pharmacology
  • Cell Line
  • Erbium* / chemistry
  • Erbium* / pharmacokinetics
  • Erbium* / pharmacology
  • Humans
  • Macrophages / cytology
  • Macrophages / metabolism*
  • Magnetic Phenomena
  • Nanoparticles / chemistry*
  • Peptides* / chemistry
  • Peptides* / pharmacokinetics
  • Peptides* / pharmacology
  • Silicon Dioxide* / chemical synthesis
  • Silicon Dioxide* / chemistry
  • Silicon Dioxide* / pharmacokinetics
  • Silicon Dioxide* / pharmacology
  • Silver* / chemistry
  • Silver* / pharmacokinetics
  • Silver* / pharmacology
  • Spectrum Analysis
  • Surface Plasmon Resonance / methods*

Substances

  • Peptides
  • Silver
  • Silicon Dioxide
  • Erbium