Discovery of α,β- and α,γ-diamino acid scaffolds for the inhibition of M1 family aminopeptidases

ChemMedChem. 2011 Nov 4;6(11):1971-6. doi: 10.1002/cmdc.201100298. Epub 2011 Aug 16.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids, Diamino / chemistry*
  • Amino Acids, Diamino / pharmacology
  • Aminobutyrates / chemistry
  • Aminopeptidases / antagonists & inhibitors*
  • Aminopeptidases / chemistry
  • Aminopeptidases / metabolism
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism
  • Binding Sites
  • Catalytic Domain
  • Crystallography, X-Ray
  • Drug Design
  • Humans
  • Methionine
  • Models, Molecular
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology*
  • Serine / chemistry
  • beta-Alanine / pharmacology

Substances

  • Amino Acids, Diamino
  • Aminobutyrates
  • Bacterial Proteins
  • Protease Inhibitors
  • beta-Alanine
  • pepN protein, Bacteria
  • 2,4-diaminobutyric acid
  • Serine
  • Methionine
  • 2,3-diaminobutanoic acid
  • Aminopeptidases
  • enkephalin degrading enzyme

Associated data

  • PDB/3PUU
  • PDB/3QJX